GLS450 4matic
All-Wheel Drive · Automatic 9-spd · Standard Sport Utility Vehicle 4WD
- MPG combined
- 21
- City / highway
- 19 / 24
- Engine
- 3.0L 6-cyl turbo supercharged
- Fuel
- Premium
- Annual fuel cost
- $3,900
- Tailpipe CO₂
- 424 g/mi

The Mercedes-Benz GLS-Class has been sold in the US from 2017 to 2027, in 11 model years covered here. The 2027 line-up has 1 trim with 21 MPG combined.
All-Wheel Drive · Automatic 9-spd · Standard Sport Utility Vehicle 4WD
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.