S6
All-Wheel Drive · Automatic (S6) · Midsize Cars
- MPG combined
- 16
- City / highway
- 14 / 21
- Engine
- 5.2L 10-cyl
- Fuel
- Premium
- Annual fuel cost
- $5,150
- Tailpipe CO₂
- 555 g/mi

The Audi S6 has been sold in the US from 2002 to 2025, in 19 model years covered here. The 2025 line-up has 1 trim with 22 MPG combined.
All-Wheel Drive · Automatic (S6) · Midsize Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.