S8 quattro
4-Wheel or All-Wheel Drive · Automatic 5-spd · Midsize Cars
- MPG combined
- 15
- City / highway
- 13 / 20
- Engine
- 4.2L 8-cyl
- Fuel
- Premium
- Annual fuel cost
- $5,500
- Tailpipe CO₂
- 592 g/mi

The Audi S8 has been sold in the US from 2001 to 2027, in 20 model years covered here. The 2027 line-up has 1 trim with 18 MPG combined.
4-Wheel or All-Wheel Drive · Automatic 5-spd · Midsize Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.