ML450 Hybrid 4matic
4-Wheel Drive · Automatic (variable gear ratios) · Sport Utility Vehicle - 4WD
- MPG combined
- 22
- City / highway
- 20 / 24
- Engine
- 3.5L 6-cyl
- Fuel
- Premium
- Annual fuel cost
- $3,750
- Tailpipe CO₂
- 404 g/mi

The Mercedes-Benz ML-Class has been sold in the US from 2000 to 2015, in 16 model years covered here. The 2015 line-up has 6 trims with 15–25 MPG combined.
4-Wheel Drive · Automatic (variable gear ratios) · Sport Utility Vehicle - 4WD
Rear-Wheel Drive · Automatic 7-spd · Sport Utility Vehicle - 2WD
Rear-Wheel Drive · Automatic 7-spd · Sport Utility Vehicle - 4WD
4-Wheel Drive · Automatic 7-spd · Sport Utility Vehicle - 4WD
4-Wheel Drive · Automatic 7-spd · Sport Utility Vehicle - 4WD
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.