IS 250
Rear-Wheel Drive · Manual 6-spd · Subcompact Cars
- MPG combined
- 21
- City / highway
- 18 / 26
- Engine
- 2.5L 6-cyl
- Fuel
- Premium
- Annual fuel cost
- $3,900
- Tailpipe CO₂
- 423 g/mi

The Lexus IS has been sold in the US from 2001 to 2026, in 26 model years covered here. The 2026 line-up has 2 trims with 22 MPG combined.
Rear-Wheel Drive · Manual 6-spd · Subcompact Cars
Rear-Wheel Drive · Automatic (S6) · Subcompact Cars
4-Wheel or All-Wheel Drive · Automatic (S6) · Subcompact Cars
Rear-Wheel Drive · Automatic (S6) · Subcompact Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.