S550
Rear-Wheel Drive · Automatic 7-spd · Large Cars
- MPG combined
- 16
- City / highway
- 14 / 21
- Engine
- 5.5L 8-cyl
- Fuel
- Premium
- Annual fuel cost
- $5,150
- Tailpipe CO₂
- 555 g/mi

The Mercedes-Benz S-Class has been sold in the US from 2000 to 2027, in 28 model years covered here. The 2027 line-up has 4 trims with 14–23 MPG combined.
Rear-Wheel Drive · Automatic 7-spd · Large Cars
4-Wheel or All-Wheel Drive · Automatic 7-spd · Large Cars
Rear-Wheel Drive · Automatic 5-spd · Large Cars
Rear-Wheel Drive · Automatic (S7) · Large Cars
Rear-Wheel Drive · Automatic (S5) · Large Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.