S500 4matic
4-Wheel Drive · Automatic 9-spd · Large Cars
- MPG combined
- 24
- City / highway
- 20 / 29
- Engine
- 3.0L 6-cyl
- Fuel
- Premium
- Annual fuel cost
- $3,400
- Tailpipe CO₂
- 372 g/mi

The Mercedes-Benz S-Class has been sold in the US from 2000 to 2027, in 28 model years covered here. The 2027 line-up has 4 trims with 14–23 MPG combined.
4-Wheel Drive · Automatic 9-spd · Large Cars
4-Wheel Drive · Automatic 9-spd · Large Cars
4-Wheel Drive · Automatic 9-spd · Large Cars
4-Wheel Drive · Automatic 9-spd · Subcompact Cars
4-Wheel Drive · Automatic 9-spd · Compact Cars
4-Wheel Drive · Automatic 9-spd · Compact Cars
Rear-Wheel Drive · Automatic 9-spd · Subcompact Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.