E320
Rear-Wheel Drive · Automatic 5-spd · Midsize Cars
- MPG combined
- 21
- City / highway
- 18 / 26
- Engine
- 3.2L 6-cyl
- Fuel
- Premium
- Annual fuel cost
- $3,900
- Tailpipe CO₂
- 423 g/mi

The Mercedes-Benz E-Class has been sold in the US from 2000 to 2027, in 28 model years covered here. The 2027 line-up has 4 trims with 25–28 MPG combined.
Rear-Wheel Drive · Automatic 5-spd · Midsize Cars
Rear-Wheel Drive · Automatic 5-spd · Midsize Station Wagons
4-Wheel or All-Wheel Drive · Automatic 5-spd · Midsize Cars
4-Wheel or All-Wheel Drive · Automatic 5-spd · Midsize Station Wagons
Rear-Wheel Drive · Automatic 5-spd · Midsize Cars
4-Wheel or All-Wheel Drive · Automatic 5-spd · Midsize Cars
Rear-Wheel Drive · Automatic 5-spd · Midsize Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.