E350
Rear-Wheel Drive · Automatic 7-spd · Midsize Cars
- MPG combined
- 20
- City / highway
- 17 / 25
- Engine
- 3.5L 6-cyl
- Fuel
- Premium
- Annual fuel cost
- $4,100
- Tailpipe CO₂
- 444 g/mi

The Mercedes-Benz E-Class has been sold in the US from 2000 to 2027, in 28 model years covered here. The 2027 line-up has 4 trims with 25–28 MPG combined.
Rear-Wheel Drive · Automatic 7-spd · Midsize Cars
4-Wheel Drive · Automatic 7-spd · Midsize Cars
4-Wheel Drive · Automatic 7-spd · Midsize Station Wagons
Rear-Wheel Drive · Automatic 7-spd · Subcompact Cars
Rear-Wheel Drive · Automatic 7-spd · Subcompact Cars
Rear-Wheel Drive · Automatic 7-spd · Midsize Cars
4-Wheel Drive · Automatic 7-spd · Midsize Cars
Rear-Wheel Drive · Automatic 7-spd · Subcompact Cars
Rear-Wheel Drive · Automatic 7-spd · Subcompact Cars
Rear-Wheel Drive · Automatic 7-spd · Midsize Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.