E
World Of EVEditorial

Mercedes-Benz E-Class

Plug-in hybridHybridDieselGasMidsize Cars

The Mercedes-Benz E-Class has been sold in the US from 2000 to 2027, in 28 model years covered here. The 2027 line-up has 4 trims with 25–28 MPG combined.

Model years

2022 E-Class trims (11)

AMG E53 4matic Plus

Hybrid

4-Wheel Drive · Automatic 9-spd · Midsize Cars

MPG combined
24
City / highway
21 / 29
Engine
3.0L 6-cyl
Fuel
Premium
Annual fuel cost
$3,400
Tailpipe CO₂
373 g/mi

AMG E53 4matic Plus Convertible

Hybrid

4-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
22
City / highway
20 / 27
Engine
3.0L 6-cyl
Fuel
Premium
Annual fuel cost
$3,750
Tailpipe CO₂
397 g/mi

AMG E53 4matic Plus Coupe

Hybrid

4-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
23
City / highway
20 / 28
Engine
3.0L 6-cyl
Fuel
Premium
Annual fuel cost
$3,550
Tailpipe CO₂
384 g/mi

E450 4matic

Hybrid

4-Wheel Drive · Automatic 9-spd · Midsize Cars

MPG combined
25
City / highway
23 / 30
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,300
Tailpipe CO₂
348 g/mi

E450 4matic All-Terrain (wagon)

Hybrid

4-Wheel Drive · Automatic 9-spd · Midsize Station Wagons

MPG combined
24
City / highway
21 / 28
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,400
Tailpipe CO₂
368 g/mi

E450 4matic Convertible

Hybrid

4-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
24
City / highway
22 / 29
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,400
Tailpipe CO₂
362 g/mi

E450 4matic Coupe

Hybrid

4-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
24
City / highway
21 / 30
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,400
Tailpipe CO₂
362 g/mi

E450 Convertible

Hybrid

Rear-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
25
City / highway
22 / 29
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,300
Tailpipe CO₂
360 g/mi

E450 Coupe

Hybrid

Rear-Wheel Drive · Automatic 9-spd · Subcompact Cars

MPG combined
25
City / highway
22 / 29
Engine
3.0L 6-cyl turbo
Fuel
Premium
Annual fuel cost
$3,300
Tailpipe CO₂
360 g/mi

E350

Gas

Rear-Wheel Drive · Automatic 9-spd · Midsize Cars

MPG combined
26
City / highway
23 / 31
Engine
2.0L 4-cyl turbo
Fuel
Premium
Annual fuel cost
$3,150
Tailpipe CO₂
342 g/mi

E350 4matic

Gas

All-Wheel Drive · Automatic 9-spd · Midsize Cars

MPG combined
24
City / highway
21 / 29
Engine
2.0L 4-cyl turbo
Fuel
Premium
Annual fuel cost
$3,400
Tailpipe CO₂
366 g/mi

Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.